Highly photogenic Dōtombori is the city's liveliest night spot and the centre of the southern part of town. Its name comes from the 400-year-old canal, Dōtombori-gawa, now lined with pedestrian walkways and with a riot of illuminated billboards glittering off its waters. Don't miss the famous Glico running man sign. South of the canal is a pedestrianised street that has dozens of restaurants vying for attention with the flashiest of signage.
For the best views, head to Ebisu-bashi, the bridge at the western end of the strip.