Six Senses Douro Valley

European flagship of the luxury-minded Six Senses group, this gorgeously renovated, award-winning 19th-century manor house is nestled on an idyllic bend in the river 5km from Régua. The rooms, suites and villas are chic and sleek, the spa is extraordinary, and the restaurant is among the region's finest, with veggies from the on-site organic gardens and wine as the centrepiece.