This charming, rather ragtag religious-art museum is housed in a wonderful old house. It hosts a small but well-displayed collection of art, labeled in English and Spanish. The most interesting exhibit describes restoration work on Santa Prisca, during which some fabulous material (including tapestries, woodwork altarpieces and rich decorative fabrics) was discovered in the basement of the house. There is also an interesting display on the Manila Galleons, which pioneered trade between the Americas and the Far East.
The Museo de Arte Virreinal is often referred to as Casa Humboldt, even though the famous German explorer and naturalist Friedrich Heinrich Alexander von Humboldt slept here for only one night in 1803.
Guided tours (free but tip expected) are sometimes available in Spanish.