Vent is currently Tokyo's hottest club, drawing top international house and techno DJs (which pull in packed crowds). It's a concrete vault of a space, with a separate dance floor and lounge area and a state-of-the-art sound system. Open Fridays and Saturdays from 11pm (though don't expect top acts to appear until 2am). Advanced tickets cut down on the pricey (usually ¥3600) cover charge.
The entrance is confusing: it's in the building right on the main intersection but you need to cross through the open foyer to the back (there's a small sign out front detailing the route).