Off the tourist trail, Prima Classe is where the ragusani play. A slick mix of concrete floors and designer Spanish lighting, it's a cafe, bar and art space in one, with rotating exhibitions, regular live music (except in summer), decent drinks and fantastic aperitivo bites. It's also a handy coffee or lunch spot if you're near the bus station, 400m to the south.
The bar hosts both emerging and established Italian musicians, playing anything from rock to funk and reggae. As for the green-themed restroom, don't leave without a look.