D.O.M Hotel

This five-star luxury hotel on graceful Via Giulia was a 17th-century convent in a former life. Marble inscriptions dating back to the 1500s juxtapose with a trio of original Andy Warhol silkscreens and exposed brick walls. After a day of sightseeing, unwind at its trendy Deer Club, a restaurant serving up fun cocktails and meals.