S Nikolis Hotel

The life’s work of builder Sotiris Nikolis and his Danish partner Marianne, this fine hotel ranges through several restored buildings and a flowery courtyard. Its dozen stylish split-level rooms feature medieval-accented quilts on dark-wood four-poster beds, marble floors, and stone and oxblood walls. Breakfast in the on-site Arxaia Agora cafe – named for the ancient marketplace that lies below – is superb.